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As with any medication, tadalafil may have potential side effects, including headache, indigestion, muscle aches, back pain, and stuffy or runny nose. In rare cases, it can cause more serious side effects such as priapism (a prolonged and painful erection) or sudden vision loss. It is important to consult a healthcare professional before starting tadalafil to ensure it is safe and appropriate for you, especially if you have any underlying medical conditions or are taking other medications.